Published December 1, 1999
by Elsevier Science .
Written in English
|The Physical Object|
|Number of Pages||372|
Beta cells (β cells) are a type of cell found in pancreatic islets that synthesize and secrete insulin and cells make up 50–70% of the cells in human islets. In patients with type I or type II diabetes, beta-cell mass and function are diminished, leading to Function: Insulin secretion. The islets of Langerhans contain alpha, beta, and delta cells that produce glucagon, insulin, and somatostatin, respectively. A fourth type of islet cell, the F (or PP) cell, is located at the periphery of the islets and secretes pancreatic polypeptide. Pancreatic Islet Biology (Stem Cell Biology and Regenerative Medicine) - Kindle edition by Anandwardhan A. Hardikar. Download it once and read it on your Kindle device, PC, phones or tablets. Use features like bookmarks, note taking and highlighting while reading Pancreatic Islet Biology (Stem Cell Biology and Regenerative Medicine). Purchase The Pancreatic Beta Cell, Volume 95 - 1st Edition. Print Book & E-Book. ISBN ,
It is understood that glucose stimulates insulin secretion in the pancreatic beta cell by means of a synergistic interaction between at least two signaling pathways. In the K (ATP) channel-dependent pathway, glucose stimulation increases the entry of extrinsic Ca2+ through voltage-gated channels by closure of the K (ATP) channels and Cited by: 3. Get this from a library! The biology of the pancreatic [beta]-cell. [E Edward Bittar; S L Howell;] -- As a result of the key advances made more than 30 years ago, specifically the ability to isolate islets of Langerhans from the pancreas, the ability to . THE CELL BIOLOGY OF THE PANCREATIC BETA CELL NIH GUIDE, Vol Num Octo RFA: DK P.T. National Institute of Diabetes and Digestive and Kidney Diseases Letter of Intent Receipt Date: Febru Application Receipt Date: Ma PURPOSE The National Institute of Diabetes and Digestive and Kidney Diseases . The Beta Cell Immunopeptidome Nadine L. Dudek and Anthony W. Purcell Autophagy and Pancreatic Beta Cells Simona Mazza and Tania Maffucci The Somatostatin Receptor in Human Pancreatic -Cells Matthias Braun Modulation of the Pancreatic Islet-Stress Axis as a Novel Potential Therapeutic Target in Diabetes Mellitus.
Robin A. Kimmel, Dirk Meyer, in Methods in Cell Biology, E Beta-Cell Proliferation. Beta-cell number increases significantly during the transition from late embryonic to postnatal and juvenile stages in zebrafish as well as in mammals (Chen et al., ; Hanley et al., ; Moro et al., ; Parsons et al., ). Although recovery from. Failure of normal beta-cell function can lead to hyperglycemia (diabetes mellitus) or hypoglycemia. While hy- glycemia is a rare and life-threatening condition in which the beta cell secretes too much insulin, diabetes mellitus is a common disorder that is fast bec- ing an epidemic. It is a major threat to human health in the 21st century. The classic model of pancreatic cancer development describes morphological as well as molecular transformation from precursor lesions into invasive carcinoma. The standard nomenclature and diagnostic criteria for classification of duct lesions has primarily been based on grades of pancreatic intraepithelial neoplasia (PanIN). The grades 1A, 1B Cited by: Beta Cell Biology We use a number of in vitro and in vivo models systems to study the molecular and cellular basis for stimulation of beta cell growth and differentiation. The aim of the groups research is to create new knowledge that can be used in prevention and treatment of Type 1 and Type 2 diabetes.